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Due to delayed gastric emptying during initiation and dose escalation, women using oral contraceptives should consider using a non-oral contraceptive or add a barrier method for 4 weeks after each dose increase

Ann Am Thorac Soc 2017;14(1):76-84

Supplementing iron unnecessarily carries risks, including GI irritation that compounds existing side effects and potential iron overload in susceptible individuals

The tension is valid and I dont think the people who push on regulatory boundaries are always wrong

Liver cancer risk reduction may be partly explained by the antisteatotic and anti-inflammatory effects of GLP-1 RAs in patients with NAFLD or metabolic syndrome (Figure 5)
Plamboeck A, Veedfald S, Deacon CF et al (2013) The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty