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Kovarik et al

November 4, 2025

In previous studies, AD was closely associated with oxidative stress, which lead to increased production of A and aberrant phosphorylation of tau protein, Excessive production of reactive oxygen species(ROS) resulted in lipid peroxidation of unsaturated fatty acids in cell membranes, causing functional impairment, aging, and apoptosis of neuronal cells, ultimately leading to memory and cognitive dysfunction [34]

The equine neutrophilic proteinase inhibitors share their target specificity with eNAP-2, but in contrast they were stable at temperatures up to 100C and the inhibitory activity remained constant at a broad pH-range

doi: 10.1016/j.jmii.2016.01.002 103 TsugawaH.MoriH.MatsuzakiJ.SatoA.SaitoY.ImotoM.et al

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