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Extracellular vesicles produced by bone marrow mesenchymal stem cells overexpressing programmed death-ligand 1 ameliorate dextran sodium sulfate-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis

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Finally, data from mouse studies show that IgG accumulates in white adipose tissue in an FcRn-dependent manner, and that knocking down the receptor by an antisense oligonucleotide targeting the encoding FCGRT gene or deleting expression of FcRn from myeloid cellseffectively turning macrophages into degradative sinks for IgG [381]surprisingly improves metabolic function in mice with diet-induced obesity [382]

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Lumbar spine intervertebral disc desiccation is associated with medical comorbidities linked to systemic inflammation