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A TriNetX database study found an increased risk of erectile dysfunction in non-diabetic men using semaglutide for weight loss
Although predominantly expressed in the adipose tissue 4 , PPAR messenger RNA and immunoreactivity has also been detected in hypothalamic nuclei governing energy balance 5 , and third ventricle adenoviral-mediated overexpression of PPAR decreases food intake in lean and diet-induced obese (DIO) mice 6
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